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pentobarbital will reduce the level or result of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Netupitant is mainly metabolized by CYP3A4; steer clear of use in patients that are chronically making use of a solid CYP3A4 inducerpentobarbital will lessen the level or outcome of